Prof. Rikard Holmdahl, MD, PhD

Medical Inflammation Research

Karolinska Institutet
Current Position:

 

Head of Division of Medical Inflammation Research
Department of Medical Biochemistry and Biophysics (MBB)
Karolinska Institutet

Contact:
Address: Scheeles väg 2, 171 77 Stockholm, Sweden
e-mail:  Rikard.Holmdahl @ ki.se
Phone:  +46-08-524 86839
Homepage:  www.inflam.mbb.ki.se

Full  CV
Appointments:
Professor in Medical Inflammation Research 1 Feb 1993 (Lund University)
Guest Professor at the Finnish Academy 1 Jan 2007 (Turku University)
Professor in Medical Inflammation Research, 1 Jan 2008 (Karolinska Institutet)
Commission of trust (selected):
1993- Head of the Medical Inflammation Research Laboratory
1996- Member of the editorial board of Scandinavian Journal of Immunology
1997- Member of the editorial board of European Journal of Immunology
1999- Associated editor for Arthritis Research
1999- Member of the international advisory board of Modern Rheumatology
2001-05 Member of the medical faculty board, Lund University
2003- Member of the Executive Committee of European Journal of Immunology
2004- Board member of Scandinavian Foundation for Immunology
Proffessional preparation:
1971-1976 Industrial employments (Nymans/Uppsala/, Alfa Laval /Tumba/, Sandvik Coromant /Stockholm/)
1976-1977 Biochemistry 1 year (Stockholm/Uppsala University)
1977-1987 Medical education 5.5 years (Uppsala University)
1985 (27 Sept)  PhD (Uppsala University)
1987 MD (Uppsala University)
1987Associate professor (docent) (Uppsala University)
1988-1989 Clinical residency training, University Hospital, Uppsala
1990-1993 Research fellow, Medical Research Council in Sweden


Educated PhD students and postdocs:

 1) Mikael Andersson 2) Tom J Goldschmidt, 3) Liselotte Jansson, 4) John A Mo, 5) Erik Michaëlsson, 6) Vivianne Malmström, 7) Carina Vingsbo-Lundberg, 8) Ulrica Brunsberg, 9) Peter Kjellén, 10) Alexandre Corthay, 11) Johan Jirholt, 12) Mikael Vestberg, 13) Ann-Sofie Hansson, 14) Åsa Johansson, 15) Shemin Lu, 16) Lars Svensson, 17) Johan Bäcklund, 18) Patrik Wernhoff, 19) Peter Olofsson, 20) Jens Holmberg, 21) Martina Johannesson, 22) Robert Bockermann, 23) Estelle Bajtner, 24) Stefan Carlsen, 25) Kutty Selva Nandakumar, 26) Lina Olsson, 071130, 27) Emma Ahlqvist, 28) Malin Hultqvist, 29) Carola Rintisch, 30) Therese Lindvall
PhD theses assistant supervision: 1) Per Larsson, 2) Inga Hansson, 3) Hai Tao Yang, 4) Ingrid Teige, 5) Jinan Li, 6) Meirav Holmdahl, 7) Jenny Karlsson, 8) Alexandra Treschow

Publications (20 selected):

  1. Holmdahl R, Karlsson M, Andersson ME, Rask L, Andersson L: Localization of a critical restriction site on the I-Abeta chain which determines susceptibility to collagen induced arthritis. Proc Natl Acad Sci (USA) 1989, 86:9475-9479.
  2. Michaëlsson E, Malmström V, Reis S, Burkhardt H, Engström Å, Holmdahl R: T cell recognition of carbohydrates on type II collagen. J Exp Med 1994, 30:745-749.
  3. Sundvall M, Jirholt J, Yang H-T, Jansson L, Engström Å, Pettersson U, Holmdahl R: Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nature Genet 1995, 10:313-317.
  4. Malmström V, Michaëlsson E, Burkhardt H, Mattsson R, Vuorio E, Holmdahl R: Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis. Proc Natl Acad Sci (USA) 1996, 93:4480-4485.
  5. Kuokkanen S, Sundvall M, Terwilliger JD, Tienari PJ, Wikström J, Holmdahl R, Pettersson U, Peltonen L: A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nature Genetics 13, 477-480. 1996
  6. Andersson EC, Hansen BE, Jacobsen H, Madsen LS, Andersen CB, Engberg J, Rothbard JB, Sönderstrup-McDevitt G, Malmström V, Holmdahl R, Svejgaard A, Fugger L: Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci U S A 95, 7574-7569. 1998.
  7. Vingsbo-Lundberg C, Nordquist N, Olofsson P, Sundvall M, Saxne T, Pettersson U, Holmdahl R: Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Gen 20, 401-404. 1998.
  8. Madsen LS, Andersson EC, Jansson L, Krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, Wucherpfennig KW, Fugger L: A humanized model for multiple sclerosis using HLA-DR2 and a human T- cell receptor. Nat Gen 23, 343-347. 1999.
  9. Bäcklund J, Carlsen S, Höger T, Holm B, Fugger L, Kihlberg J, Burkhardt H, Holmdahl R: Predominant selection of T cells specific for glycosylated collagen type II peptide (263-270) in humanized transgenic mice and in rheumatoid arthritis. Proc Natl Acad Sci U S A 99, 9960-9965. 2002.
  10. Olofsson P, Holmberg J, Tordsson J, Lu S, Åkerström B, Holmdahl R: Positional identification of ncf1 as an arthritis severity regulating gene in rats. Nat Gen 33:25-32, 2003
  11. Blom T, Franzen A, Heinegard D, Holmdahl R: Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease". Science 299, 1845. 2003.
  12. Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 101:12646-51, 2004.   
  13. Gelderman KA, Hultqvist M, Holmberg J, Olofsson P, Holmdahl R: T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc Natl Acad Sci U S A; 103, 12831-6. 2006.
  14. Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R: A new arthritis therapy with oxidative burst inducers. PLoS Medicine; 3, 2006.
  15. Jonsson IM, Verdrengh M, Brisslert M, Lindblad S, Bokarewa M, Islander U, Carlsten H, Ohlsson C, Nandakumar KS, Holmdahl R, Tarkowski A: Ethanol prevents development of destructive arthritis. Proc Natl Acad Sci U S A; 104, 258-63. 2007.
  16. Gelderman, K. A., M. Hultqvist, A. Pizzolla, M. Zhao, K. S. Nandakumar, R. Mattsson, and R. Holmdahl. 2007. Macrophages suppress T cell responses and arthritis development by producing Reactive Oxygen Species J Clin Invest 117:3020-3028.
  17. Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, J. S., Slutsky, A. S., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, C. J. and Penninger, J. M., Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 2008. 133: 235-249.
  18. Rintisch, C., Ameri, J., Olofsson, P., Luthman, H. and Holmdahl, R., Positional identification of the V lambda gene and its association with rheumatoid factor production and eosinophilic inflammation in rats. Proc Natl Acad Sci U S A 2008. 105:14005-10.
  19. Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström Å, Thunnisein M, Holmdahl R: Structure and pathogenicity of antibodies specific for citrullinated collagen type II in Experimental Arthritis. J Exp Med 2009; in press.

Updated: March 10, 2010